Cytotoxic Drug Safety Cabinet (CDSC) Service
Cytotoxic drug safety cabinets (CDSC) are critical in sterility and safety for operators, maintenance personnel and the product. Regular testing of all cabinets should be completed at least once a year to ensure their longevity and functionality.
Some of our specialist services include:
Cytotoxic Drug Safety cabinets (CDSC) are designed for applications where cytotoxic materials are being used, offering Product, Personnel and Technician protection.
Protection of personnel and the immediate surroundings from aerosols, particles or vapours, which may be liberated in the preparation, manipulation and compounding of hazardous products.
Protection of products so that they can be manipulated or compounded aseptically in a clean, controlled environment.
Protection of maintenance and testing personnel from exposure to toxic materials that ,may be found in cabinet filters and internal cabinet surfaces.
It is important to note that Class I & II Biological Safety Cabinets are unsuitable for handling cytotoxic materials that are not inactivated by routine decontamination. This is why it is critical to engage a specialist Service Company such as AES Environmental who is not only familiar with BSC cabinets but also aware of the additional requirements unique to maintaining CDSC cabinets.
Filter Installation Integrity: Filter integrity is determined by: AS 1807:2021 Cl 4.4 determination of integrity of terminally mounted HEPA and AS 1807.7 determination of integrity of non- terminally mounted HEPA.
Containment at the aperture: Containment at the aperture is determined by either AS 1807:2021 Cl 4.9 air barrier containment or AS 1807:2021 Cl 4.12 air barrier test
Work Zone Integrity: Tested in accordance to AS1807:2021 Cl 4.3 Determination of work zone integrity
Air velocity and uniformity in the workzone: Tested in accordance to AS 1807:2021 Cl 4.1 determination of air velocity and uniformity
Alarm Operational Adjustment: Tested in accordance to preset systems by the manufacturer.
Particle counts: Particle counts are tested at the working positions of the workzone to ISO 14644.1
Vibration: Tested in accordance to AS 1807:2021 Cl 4.6 determination of vibration.
Sound Level: Tested in accordance to AS 1807:2021 Cl 4.7 determination of sound level
Lighting: Tested in accordance to AS 1807:2021 Cl 4.5 determination of illuminance
Ultraviolet radiation: Tested in accordance to AS 1807:2021 Cl 4.10 Intensity of radiation from UV lamps
All cytotoxic Drug safety cabinets should have a carbon filter fitted to the exhaust of the cabinet to filter 100% of exhaust air volume.
Carbon filters should be replaced annually or in the event of a high risk spill. Please note, removal of all filters should follow the appropriate procedure (see next page for more information regarding disposal/removal).
Before HEPA a contaminated HEPA is removed, it should be sprayed with an adhesive to trap hazardous material on the filter. After the sealing plate is fitted over the filter face, seal the edges of the sealing plate to ensure all contaminated surfaces of the gasket and filter casting are effectively covered.
To ensure cytotoxic waste is disposed of safely, ALL filters (including HEPA filters, Activated carbon filters and pre-filters) within the Cytotoxic cabinets need to be disposed in the following procedure: